Published Studies that Reference the Use of TissueScope™ Scanners

Cerebrovascular and blood-brain barrier impairments in Huntington’s disease: potential implications for its pathophysiology

Publication: Annals of Neurology, 2015

Quantitative Ultrasound Spectroscopic Imaging for Characterization of Disease Extent in Prostate Cancer Patients

Publication: Translational Oncology, 2015

Non-invasive evaluation of breast cancer response to chemotherapy using quantitative ultrasonic backscatter parameters

Publication: Medical Imaging Analysis, 2015

Prostate clinical study of a full inversion unconstrained ultrasound elastography technique

Publication: SPIE Medical Imaging, 2014

Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda

Publication: Mucosal Immunology, 2014

Go Large! Opportunities and Challenges Presented by Whole-Mount Histopathology

Publication: Pathology Informatics, 2014

Targeting the Renin–Angiotensin System Combined With an Antioxidant Is Highly Effective in Mitigating Radiation-Induced Lung Damage

Publication: International Journal of Radiation Oncology, 2014

Early prediction of therapy responses and outcomes in breast cancer patients using quantitative ultrasound spectral texture

Publication: Oncotarget, 2014

HIV Infection in Uncircumcised Men Is Associated With Altered CD8 T-Cell Function But Normal CD4 T-cell Numbers in the Foreskin

Publication: Journal of Infectious Diseases, 2014

Biomechanical Modeling and Inverse Problem Based Elasticity Imaging for Prostate Cancer Diagnosis

Publication: PhD thesis, Western

A Texture Based Approach to Automated Detection of Diagnostically Relevant Regions in Breast Digital Pathology

Publication: MICCAI, Workshop on Breast Image Analysis, 2013

Irinotecan Sucrosofate Liposome Injection, MM-398, Demonstrates Superior Activity and Control of Hypoxia as Measured through Longitudinal Imaging Using [18F]FAZA PET Compared to Free Irinotecan in a Colon Adenocarcinoma Xenograft Model

Publication: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, 2013

Hypoxic activation of the PERK/eIF2a arm of the unfolded protein response promotes metastasis through induction of LAMP3

Publication: Clinical Cancer Research, 2013

Quantification of Fibrosis in Infarcted Swine Hearts by ex vivo Late Gadolinium Enhancement and Diffusion-Weighted MRI Methods

Publication: Physics in Medicine and Biology, 2013

3D Co-registration of MRI and Histology in a Mouse Model of Obesity

Publication: ImNO – Pre-Clinical Imaging, 2013

Development of a Multi-Modality Imaging Pipeline for the Interrogation of Phenotypic Differences in the Tumor Microenvironment of Patient-Derived Colon Cancer Xenografts

Publication: ImNO – Adaptive Interventions in Radiation Oncology, 2013

Quantitative Ultrasound Evaluation of Tumour Cell Death Response in Locally Advanced Breast Cancer Patients Receiving Chemotherapy

Publication: Clinical Cancer Research, 2013

Evaluation of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer Using Ultrasound Elastography

Publication: Translational Oncology, 2013

Development and Proof-of-Concept of Three-Dimensional Lung Histology Volumes

Publication: Medical Imaging: Biomedical Applications in Molecular, Structural, and Functional Imaging, 2012

Sequence Dependence of MEK Inhibitor AZD6244 Combined with Gemcitabine for Treatment of Biliary Cancer

Publication: Clinical Cancer Research, 2012

Diffuse Optical Imaging for Monitoring Treatment Response in Breast Cancer Patients

Publication: IEEE Engineering in Medicine and Biology, 2012

WFDC1/ps20: A Host Factor that Influences the Neutrophil Response to Murine Hepatitis Virus (MHV) 1 Infection

Publication: Antiviral Research, 2012

3D Pathology Volumetric Technique: A Method for Calculating Breast Tumour Volume from Whole-Mount Serial Section Images

Publication: International Journal of Breast Cancer, 2012

Diffuse Optical Spectroscopy Evaluation of Treatment Response in Women with Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy

Publication: Translational Oncology, 2012

Targeting Tumour Metabolism through HIF-1 Inhibition Enhances Radiation Response in Cervix and Head and Neck Xenograft Tumours

Publication:MSc Thesis, 2011

Digital Transplantation Pathology: Combining Whole Slide Imaging, Multiplex Staining and Automated Image Analysis

Publication: American Journal of Transplantation, 2011

Increasing specimen coverage using digital whole-mount breast pathology: Implementation, clinical feasibility and application in research

Publication: Computerized Medical Imaging and Graphics, 2011

Biomechanical Property Quantification of Prostate Cancer by Quasi-static MR Elastography at 7 Telsa of Radical Prostatectomy, and Correlation with Whole Mount Histology

Publication: The International Society for Magnetic Resonance in Medicine, 2011

Megapixel Digital PCR

Publication: Nature Methods, 2011

Evaluation of Microscopic Disease in Oral Tongue Cancer Using Whole-Mount Histopathologic Techniques: Implications for the Management of Head-and-Neck Cancers

Publication: International Journal of Radiation Oncology * Biology * Physics, 2011

Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically-grown primary xenografts of human pancreatic cancer

Publication: Cancer Research, 2011

Evaluating the Extent of Cell Death in 3D High Frequency Ultrasound by Registration with Whole Mount-tumor Histopathology

Publication: Medical Physics, 2010

Registration of In Vivo Prostate Magnetic Resonance Images to Digital Histopathology Images

Publication: Prostate Cancer Imaging, Computer-Aided Diagnosis, Prognosis and Intervention/ Lecture Notes in Computer Science/ Robarts Research Institute/ University of Western Ontario, 2010

Technical Note: Fiducial Markers for Correlation of Whole-Specimen Histopathology with MR Imaging at 7 Tesla

Publication: Medical Physics, 2010

Activation of Src and Src-associated Signaling Pathways in Relation to Hypoxia in Human Cancer Zenograft Models

Publication: International Journal of Cancer, 2008

Developing a Methodology for Three-Dimensional Correlation of PET-CT images and Whole-Mount Histopathology in Non-Small-Cell Lung Cancer

Publication: Current Oncology, 2008

Effect of Distributional Heterogeneity on the Analysis of Tumor Hypoxia Based Carbonic Anhydrase IX

Publication: Laboratory Investigation, 2007

Imaging and Modulating Antisense Microdistribution in Solid Human Xenograft Tumor Models

Publication: Clinical Cancer Research, 2007

Measurements of Aneurysm Morphology Determined by 3-D Micro-Ultrasound Imaging as Potential Quantitative Biomarkers in a Mouse Aneurysm Model

Publication: Ultrasound in Medicine & Biology, 2007

Measurement of Signaling Pathway Activities in Solid Tumor Fine-needle Biopsies by Slide-based Cytometry

Publication: Diagnostic Molecular Pathology, 2007

Predictive and Pharmacodynamic Biomarker Studies in Tumor and Skin Tissue Samples of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Treated With Erlotinib

Publication: Journal of Clinical Oncology, 2007

Acquiring Multiple Images of Large Tissue Sections in Both Fluorescence and Transmitted Light using the Laser Scanning Confocal TISSUEscope

XXXIII International Congress of the International Society for Analytical Cytology, 2006

Multiplexed and quantitative study of biomarker expression in tumor specimens using quantum dots

Publication: SPIE – Colloidal Quantum Dots for Biomedical Applications, 2006

A Phase 2 Clinical and Pharmacodynamic Study of Temsirolimus in Advanced Neuroendocrine Carcinomas

Publication: British Journal of Cancer, 2006

A New Wide Field-of-view Confocal Imaging System and its Applications in Drug Discovery and Pathology

Publication: Optical Methods in Drug Discovery and Development, 2005

A Phase 2 Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer

Publication: Clinical Cancer Research, 2005

Hyperspectral Unmixing for Removing Autofluorescence from Paraffin-Embedded, Formalin-fixed Tissue Sections

Publication: SPIE Photonic Applications in Biosensing and Imaging, 2005

A High-resolution MACROscope with Differential Phase Contrast, Transmitted Light, Confocal Fluorescence, and Hyperspectral Capabilities for Large-area Tissue Imaging

Publication: IEEE Selected Topics in Quantum Electronics, 2005